2026-05-22T17:25:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/186872024-02-27T15:08:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Martínez-Montoro, José Ignacio author Ocaña-Wilhelmi, Luis author Soler-Humanes, Rocío author Motahari-Rad, Hanieh author González-Jiménez, Andrés author Rivas-Becerra, José author Rodríguez-Muñoz, Alba author Moreno-Ruiz, Francisco J author Tomé, Mónica author Rodríguez-Capitán, Jorge author García-Fuentes, Eduardo author Tinahones, Francisco J author Garrido-Sánchez, Lourdes author Murri, Mora author 2022-06-25 Zinc-α2 glycoprotein (ZAG) is an adipokine involved in adipocyte metabolism with potential implications in the pathogenesis of metabolic disorders. Our aim was to evaluate the relationship between visceral (VAT) and subcutaneous adipose tissue (SAT) ZAG expression and metabolic parameters in patients with class III obesity, along with the impact of basal ZAG expression on short- and medium-term outcomes related to bariatric surgery. 41 patients with class III obesity who underwent bariatric surgery were included in this study. ZAG gene expression was quantified in SAT and VAT. Patients were classified into two groups according to SAT and VAT ZAG percentile. Anthropometric and biochemical variables were obtained before and 15 days, 45 days, and 1 year after surgery. The lower basal SAT ZAG expression percentile was associated with higher weight and waist circumference, while the lower basal VAT ZAG expression percentile was associated with higher weight, waist circumference, insulin, insulin resistance, and the presence of metabolic syndrome. Basal SAT ZAG expression was inversely related to weight loss at 45 days after surgery, whereas no associations were found between basal VAT ZAG expression and weight loss after surgery. Additionally, a negative association was observed between basal SAT and VAT ZAG expression and the decrease of gamma-glutamyl transferase after bariatric surgery. Therefore, lower SAT and VAT ZAG expression levels were associated with an adverse metabolic profile. However, this fact did not seem to confer worse bariatric surgery-related outcomes. Further research is needed to assess the clinical significance of the role of ZAG expression levels in the dynamics of hepatic enzymes after bariatric surgery. 10.3390/biomedicines10071502 2227-9059 Biomedicines http://hdl.handle.net/10668/20839 35884810 http://hdl.handle.net/20.500.12105/18687 adipose tissue bariatric surgery gene expression metabolic syndrome morbid obesity zinc-α2 glycoprotein Evaluation of Adipose Tissue Zinc-Alpha 2-Glycoprotein Gene Expression and Its Relationship with Metabolic Status and Bariatric Surgery Outcomes in Patients with Class III Obesity.