2026-08-29T13:36:43Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/186822024-02-27T15:08:44Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16981

00925njm 22002777a 4500 dc Martínez-Sánchez, María Antonia author Núñez-Sánchez, María Ángeles author Balaguer-Román, Andrés author Oliva-Bolarín, Alba author Pujante-Gilabert, Gabriel author Hernández-Agüera, Quiteria author Mesa-López, María José author Egea-Valenzuela, Juan author Queipo-Ortuño, María Isabel author Ruiz-Alcaraz, Antonio José author Ferrer-Gómez, Mercedes author Gil-Martínez, José author Ramos-Molina, Bruno author 2022-06-22 Colorectal cancer (CRC) is the third most common cancer and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including heritable and environmental factors, which are the latest to be closely associated with nutritional habits, physical activity, obesity, and the gut microbiota. The latter may also play a key role in CRC prognosis and derived complications in patients undergoing surgery. This is a single-center, open, controlled, randomized clinical trial, in patients with scheduled surgical intervention for CRC. The primary objective is to assess whether a pre-surgical nutritional intervention, based on a high-fiber diet rich in polyunsaturated fatty acids (PUFAs), can reduce disturbances of the gut microbiota composition and, consequently, the rate of post-surgical complications in patients with CRC. Patients will be randomized in a 1:1 ratio after receiving a diagnosis of CRC. In the control arm, patients will receive standard nutritional recommendations, while patients in the intervention arm will be advised to follow a high-fiber diet rich in PUFAs before surgery. Participants will be followed up for one year to evaluate the overall rate of postsurgical complications, recurrences of CRC, response to adjuvant therapy, and overall/disease-free survival. 10.3390/jcm11133613 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21302 35806897 http://hdl.handle.net/20.500.12105/18682 anastomotic leak colorectal cancer colorectal surgery gut microbiota nutritional therapy Gut Microbiome Modification through Dietary Intervention in Patients with Colorectal Cancer: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial in Patients with Scheduled Surgical Intervention for CRC.