2026-07-22T05:26:27Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/186732024-02-27T15:08:37Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Giner-Galvañ, Vicente author Pomares-Gómez, Francisco José author Quesada, José Antonio author Rubio-Rivas, Manuel author Tejada-Montes, Javier author Baltasar-Corral, Jesús author Taboada-Martínez, María Luisa author Sánchez-Mesa, Blanca author Arnalich-Fernández, Francisco author Del Corral-Beamonte, Esther author López-Sampalo, Almudena author Pesqueira-Fontán, Paula María author Fernández-Garcés, Mar author Gómez-Huelgas, Ricardo author Ramos-Rincón, José Manuel author On Behalf Of The Semi-Covid-Network, author 2022-06-13 Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551−0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001−1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865−0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188−1.819; p < 0.001). Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course. 10.3390/biomedicines10061393 2227-9059 Biomedicines http://hdl.handle.net/10668/20835 35740416 http://hdl.handle.net/20.500.12105/18673 C-reactive protein COVID-19 comorbidity prognosis serum albumin syndemic C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19.