2026-04-30T17:16:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/186692024-02-27T15:08:33Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Vega-Núñez, Amanda
author
Gómez-Sánchez-Lafuente, Carlos
author
Mayoral-Cleries, Fermín
author
Bordallo, Antonio
author
Rodríguez de Fonseca, Fernando
author
Suárez, Juan
author
Guzmán-Parra, José
2024-02-27T15:08:33Z
2024-02-27T15:08:33Z
2022-06-09
10.3390/biomedicines10061368
2227-9059
Biomedicines
http://hdl.handle.net/10668/20834
35740389
http://hdl.handle.net/20.500.12105/18669
Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the relationship between inflammatory and neurotrophic factors and clinical, social and environmental factors involved in the development and the characterization of BD. Web of Science, PubMed, PsycINFO, Scopus and Science Direct were searched by two independent reviewers. The systematic review was registered in PROSPERO (CRD42020180626). A total of 51 studies with 4547 patients with a diagnosis of BD were selected for systematic review. Among them, 18 articles were included for meta-analysis. The study found some evidence of associations between BDNF and/or inflammatory factors and different stressors and functional and cognitive impairment, but limitations prevented firm conclusions. The main finding of the meta-analysis was a negative correlation between circulating levels of BDNF and depression severity score (standardized mean difference = -0.22, Confidence Interval 95% = -0.38, -0.05, p = 0.01). Evidence indicates that BDNF has a role in the depressive component of BD. However, the poor consistency found for other inflammatory mediators clearly indicates that highly controlled studies are needed to identity precise biomarkers of this disorder.
eng
BDNF
biomarker
bipolar disorder
clinical factors
cytokines
depression
mania
meta-analysis
neurotrophins
systematic review
Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis.
research article