2026-04-29T04:09:25Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/186672024-09-21T23:03:24Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Patti, Francesco author Chisari, Clara Grazia author Fernández, Óscar author Sarroca, Jorge author Ferrer-Picón, Elena author Hernández Vicente, Francisco author Vila Silván, Carlos 2024-02-27T15:08:32Z 2024-02-27T15:08:32Z 2022-06-07 http://hdl.handle.net/10668/19955 http://hdl.handle.net/20.500.12105/18667 35590453 10.1111/ene.15412 1468-1331 European journal of neurology Nabiximols is a therapeutic option for patients with multiple sclerosis (MS) spasticity whose symptoms are poorly controlled by conventional oral first-line medications. This study aimed to assess the relationship between changes in spasticity severity (measured on the 0-10 numeric rating scale [NRS]) and the presence of associated symptoms in patients treated with nabiximols, and to investigate the presence of the newly described 'spasticity-plus syndrome'. We analyzed real-world data from the Italian Medicines Agency e-Registry on 1138 patients with MS spasticity who began treatment with nabiximols. Evaluation time points were baseline, 4 weeks, and 3, 6, 12 and 18 months after treatment start. Common symptoms associated with MS spasticity in this cohort were pain (38.4% at baseline), sleep disturbances (32.7%), and spasms/cramps (28.5%). Pain was frequently clustered with sleep disturbances (57.2% of pain cases) and spasms/cramps (43.9%). Approximately one-third of patients with data at all evaluation time points maintained treatment at 18 months. Nabiximols reduced the baseline mean spasticity 0-10 NRS score by 24.6% at Week 4, and by 33.9% at 18 months in treatment continuers. Nabiximols resolved a range of MS spasticity-associated symptoms at Week 4, and after 18 months in treatment continuers. This real-world analysis supports the concept of a spasticity-plus syndrome and suggests that nabiximols can favorably impact a range of spasticity-associated symptoms. eng e-Registry analysis multiple sclerosis nabiximols spasticity-plus syndrome spasticity-related symptoms A real-world evidence study of nabiximols in multiple sclerosis patients with resistant spasticity: Analysis in relation to the newly described 'spasticity-plus syndrome'. research article