2026-06-14T03:37:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/186472024-09-21T21:06:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16958
Repisalud
author
Sanchez-Varo, Raquel
author
Mejias-Ortega, Marina
author
Fernandez-Valenzuela, Juan Jose
author
Nuñez-Diaz, Cristina
author
Caceres-Palomo, Laura
author
Vegas-Gomez, Laura
author
Sanchez-Mejias, Elisabeth
author
Trujillo-Estrada, Laura
author
Garcia-Leon, Juan Antonio
author
Moreno-Gonzalez, Ines
author
Vizuete, Marisa
author
Vitorica, Javier
author
Baglietto-Vargas, David
author
Gutierrez, Antonia
2024-02-27T15:07:21Z
2024-02-27T15:07:21Z
2022-05-12
10.3390/ijms23105404
1422-0067
International journal of molecular sciences
http://hdl.handle.net/10668/21157
35628216
http://hdl.handle.net/20.500.12105/18647
Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor protein (APP) and presenilins (PS) genes. However, due to the repeated failure of translational applications from animal models to human patients, along with the recent advances in genetic susceptibility and our current understanding on disease biology, these models have evolved over time in an attempt to better reproduce the complexity of this devastating disease and improve their applicability. In this review, we provide a comprehensive overview about the major pathological elements of human AD (plaques, tauopathy, synaptic damage, neuronal death, neuroinflammation and glial dysfunction), discussing the knowledge that available mouse models have provided about the mechanisms underlying human disease. Moreover, we highlight the pros and cons of current models, and the revolution offered by the concomitant use of transgenic mice and omics technologies that may lead to a more rapid improvement of the present modeling battery.
eng
Alzheimer’s disease
amyloid
astrocytes
microglia
neurodegeneration
oligodendrocytes
tau
transgenic mice
Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.
research article