2026-06-30T03:03:59Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/186462024-09-21T23:20:51Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Martínez-Montoro, José Ignacio author Damas-Fuentes, Miguel author Fernández-García, José Carlos author Tinahones, Francisco J author 2022-05-12 In the last decades, obesity has reached epidemic proportions worldwide. Obesity is a chronic disease associated with a wide range of comorbidities, including insulin resistance and type 2 diabetes mellitus (T2D), which results in significant burden of disease and major consequences on health care systems. Of note, intricate interactions, including different signaling pathways, are necessary for the establishment and progression of these two closely related conditions. Altered cell-to-cell communication among the different players implicated in this equation leads to the perpetuation of a vicious circle associated with an increased risk for the development of obesity-related complications, such as T2D, which in turn contributes to the development of cardiovascular disease. In this regard, the dialogue between the adipocyte and pancreatic beta cells has been extensively studied, although some connections are yet to be fully elucidated. In this review, we explore the potential pathological mechanisms linking adipocyte dysfunction and pancreatic beta cell impairment/insulin resistance. In addition, we evaluate the role of emerging actors, such as the gut microbiome, in this complex crosstalk. 10.3389/fendo.2022.869951 1664-2392 Frontiers in endocrinology http://hdl.handle.net/10668/20565 35634505 http://hdl.handle.net/20.500.12105/18646 adipokines adipose tissue beta cell diabetes gut microbiota inflammation insulin resistance Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review.