2026-05-21T23:07:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/186442025-04-04T09:09:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16958col_20.500.12105_16970col_20.500.12105_16978
Repisalud
author
Biezma, María Isabel
author
Muñoz, Patricia
author
De la Villa, Sofía
author
Fariñas-Álvarez, Mª Carmen
author
Arnáiz de Las Revillas, Francisco
author
Gutierrez-Carretero, Encarnación
author
de Alarcón, Arístides
author
Rodríguez-García, Raquel
author
Llopis, Jaume
author
Goenaga, Miguel Ángel
author
Gutierrez-Villanueva, Andrea
author
Plata, Antonio
author
Vidal, Laura
author
Martínez-Sellés, Manuel
author
On Behalf Of Games,
2024-02-27T15:07:19Z
2024-02-27T15:07:19Z
2022-05-09
10.3390/jcm11092651
2077-0383
Journal of clinical medicine
http://hdl.handle.net/10668/21284
35566777
http://hdl.handle.net/20.500.12105/18644
Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008−2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16−1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21−1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06−1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26−2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.
eng
diabetes mellitus
in-hospital mortality
infective endocarditis
one-year mortality
organ damage
prognosis
Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences.
research article