2026-07-21T14:14:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/186312024-02-27T15:07:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16969col_20.500.12105_16983

00925njm 22002777a 4500 dc Wang, Xuejie author Olveira, Casilda author Girón, Rosa author García-Clemente, Marta author Máiz, Luis author Sibila, Oriol author Golpe, Rafael author Menéndez, Rosario author Rodríguez-López, Juan author Prados, Concepción author Martinez-García, Miguel Angel author Rodriguez, Juan Luis author de la Rosa, David author Qin, Liyun author Duran, Xavier author Garcia-Ojalvo, Jordi author Barreiro, Esther author 2022-04-30 We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann-Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (n = 337) and (2) below-threshold (n = 697) groups. Patients above the threshold showed significantly worse lung function parameters and nutritional status, while systemic inflammation levels were higher than in the below-threshold patients. In the latter group, the proportions of patients with mild disease were greater, while a more severe disease was present in the above-threshold patients. According to the blood neutrophil counts using biostatistics analyses, two distinct clinical phenotypes of stable patients with non-CF bronchiectasis were defined. Patients falling into the above-threshold cluster were more severe. Severity was characterized by a significantly impaired lung function parameters and nutritional status, and greater systemic inflammation. Phenotypic profiles of bronchiectasis patients are well defined as a result of the cluster analysis of combined systemic and respiratory variables. 10.3390/biomedicines10051044 2227-9059 Biomedicines http://hdl.handle.net/10668/20829 35625780 http://hdl.handle.net/20.500.12105/18631 biostatistics analyses bronchiectasis bronchiectasis severity scores clinical outcomes multivariate analyses neutrophilic inflammation phenotypic clusters Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes.