2026-07-22T12:31:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/186142024-02-27T15:06:58Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16959
Repisalud
author
Martínez-Montoro, José Ignacio
author
García-Fontana, Beatriz
author
García-Fontana, Cristina
author
Muñoz-Torres, Manuel
2024-02-27T15:06:58Z
2024-02-27T15:06:58Z
2022-04-14
10.3390/jcm11082206
2077-0383
Journal of clinical medicine
http://hdl.handle.net/10668/21271
35456299
http://hdl.handle.net/20.500.12105/18614
Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM). However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry (DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS), high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation, are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of conventional tools for the evaluation of bone fragility and review the current evidence on novel approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.
eng
bone fragility
bone quality
bone structure
fracture risk
type 2 diabetes mellitus
Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review.
research article