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oai:repisalud.isciii.es:20.500.12105/186142024-02-27T15:06:58Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16959

00925njm 22002777a 4500 dc Martínez-Montoro, José Ignacio author García-Fontana, Beatriz author García-Fontana, Cristina author Muñoz-Torres, Manuel author 2022-04-14 Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM). However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry (DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS), high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation, are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of conventional tools for the evaluation of bone fragility and review the current evidence on novel approaches for the assessment of quality and bone microstructure alterations in patients with T2DM. 10.3390/jcm11082206 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21271 35456299 http://hdl.handle.net/20.500.12105/18614 bone fragility bone quality bone structure fracture risk type 2 diabetes mellitus Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review.