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00925njm 22002777a 4500 dc Martín-Peláez, Sandra author Serra-Majem, Lluis author Cano-Ibáñez, Naomi author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Lassale, Camille author Martínez, Jose Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramón author Tinahones, Francisco J author Lapetra, José author Fernández-Aranda, Fernando author Bueno-Cavanillas, Aurora author Tur, Josep A author Martín, Vicente author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emili author Toledo, Estefanía author Nishi, Stephanie K author Sorli, Jose V author Malcampo, Mireia author Zulet, M Ángeles author Moreno-Rodríguez, Anaí author Cueto-Galán, Raquel author Vivancos-Aparicio, Diego author Colom, Antoni author García-Ríos, Antonio author Casas, Rosa author Bernal-López, M Rosa author Santos-Lozano, Jose Manuel author Vázquez, Zenaida author Gómez-Martínez, Carlos author Ortega-Azorín, Carolina author Del Val, Jose Luís author Abete, Itziar author Goikoetxea-Bahon, Amaia author Pascual, Elena author Becerra-Tomás, Nerea author Chillarón, Juan J author Sánchez-Villegas, Almudena author 2022-04-13 Background: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870). Martín-Peláez S, Serra-Majem L, Cano-Ibáñez N, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. Lim L-L, editor. PLoS One. 2022 Apr 13;17(4):e0265079. 10.1371/journal.pone.0265079 1932-6203 PloS one http://hdl.handle.net/10668/20422 http://hdl.handle.net/20.500.13003/18032 35417452 L2017726311 2-s2.0-85128254842 http://hdl.handle.net/20.500.12105/18613 Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study