2026-06-14T03:51:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/186002024-02-27T14:58:06Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Cantero-García, Noelia author Flores-Burgess, Antonio author Ladrón de Guevara-Miranda, David author Serrano, Antonia author García-Durán, Laura author Puigcerver, Araceli author Fuxe, Kjell author Narváez, José Ángel author Santín, Luis Javier author Díaz-Cabiale, Zaida author Millón, Carmelo author 2022-02-09 Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin (1-15) [GAL(1-15)] on escitalopram (ESC)-mediated effect in alcohol consumption using the alcohol self-administration test, the nuclei involved in the effect, and whether GAL(1-15) + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1-15) + ESC combination substantially reduced alcohol intake in the alcohol self-administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1-15) + ESC coadministration significantly decreases the number of C-Fos-IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1-15) reversed adverse ESC-mediated effects in the depression-related behavioural test and forced swimming test. The results open up the possibility of using GAL(1-15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression. 10.3390/biomedicines10020412 2227-9059 Biomedicines http://hdl.handle.net/10668/20818 35203621 http://hdl.handle.net/20.500.12105/18600 Galanin (1–15) alcohol depression escitalopram The Combination of Galanin (1-15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression.