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00925njm 22002777a 4500 dc Tresserra-Rimbau, Anna author Castro-Barquero, Sara author Becerra-Tomás, Nerea author Babio, Nancy author Martínez-González, Miguel Ángel author Corella, Dolores author Fitó, Montserrat author Romaguera, Dora author Vioque, Jesús author Alonso-Gomez, Angel M author Wärnberg, Julia author Martínez, José Alfredo author Serra-Majem, Luís author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Pintó, Xavier author Tur, Josep A author López-Miranda, José author Cano-Ibáñez, Naomi author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Daimiel, Lidia author Martín Sánchez, Vicente author Vidal, Josep author Vázquez, Clotilde author Ros, Emili author Basterra, Francisco Javier author Fernández de la Puente, María author Asensio, Eva M author Castañer, Olga author Bullón-Vela, Vanessa author Tojal-Sierra, Lucas author Gómez-Gracia, Enrique author Cases-Pérez, Eugenio author Konieczna, Jadwiga author García-Ríos, Antonio author Casañas-Quintana, Tamara author Bernal-Lopez, María Rosa author Santos-Lozano, José Manuel author Esteve-Luque, Virginia author Bouzas, Cristina author Vázquez-Ruiz, Zenaida author Palau-Galindo, Antoni author Barragan, Rocio author López Grau, Mercè author Razquín, Cristina author Goicolea-Güemez, Leire author Toledo, Estefanía author Vergaz, Manel Vila author Lamuela-Raventós, Rosa M author Salas-Salvadó, Jordi author 2022-02-04 Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D. Tresserra-Rimbau A, Castro-Barquero S, Becerra-Tomás N, Babio N, Martínez-González M, Corella D, et al. Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial. Antioxidants. 4 feb 2022;11(2). 10.3390/antiox11020316 2076-3921 Antioxidants (Basel, Switzerland) http://hdl.handle.net/10668/20774 http://hdl.handle.net/20.500.13003/18595 35204199 2-s2.0-85124207720 http://hdl.handle.net/20.500.12105/18596 765359900001 HbA1c Mediterranean diet Antioxidants Flavonoids Glucose Glycosylated hemoglobin Metabolic syndrome Obesity Phenolic acids Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial