2026-04-27T07:47:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185882024-09-21T21:43:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16982
Repisalud
author
Guerrero-Orriach, José Luis
author
Carmona-Luque, Maria Dolores
author
Gonzalez-Alvarez, Laura
2024-02-27T14:57:57Z
2024-02-27T14:57:57Z
2022-01-25
http://hdl.handle.net/10668/21137
http://hdl.handle.net/20.500.12105/18588
35163284
10.3390/ijms23031360
1422-0067
International journal of molecular sciences
Heart disease requires a surgical approach sometimes. Cardiac-surgery patients develop heart failure associated with ischemia induced during extracorporeal circulation. This complication could be decreased with anesthetic drugs. The cardioprotective effects of halogenated agents are based on pre- and postconditioning (sevoflurane, desflurane, or isoflurane) compared to intravenous hypnotics (propofol). We tried to put light on the shadows walking through the line of the halogenated anesthetic drugs' effects in several enzymatic routes and oxidative stress, waiting for the final results of the ACDHUVV-16 clinical trial regarding the genetic modulation of this kind of drugs.
eng
ACDHUVV-16
halogenated
heart failure
postconditioning
preconditioning
Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress.
research article