2026-08-10T01:28:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/185862024-02-27T14:57:53Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Godoy-Ortiz, Ana author Alba-Bernal, Alfonso author Pascual, Javier author Comino-Méndez, Iñaki author Alba, Emilio author 2022-01-24 Invasive breast cancer (BC) is the most common cancer in women with a slightly increasing yearly incidence. BC immunohistochemical characterisation is a crucial tool to define the intrinsic nature of each tumour and personalise BC patients' clinical management. In this regard, the characterisation of human epidermal growth factor receptor 2 (HER2) status guides physicians to treat with therapies tailored to this membrane receptor. Standardly, a tumour solid biopsy is therefore required, which is an invasive procedure and has difficulties to provide the complete molecular picture of the tumour. To complement these standard-of-care approaches, liquid biopsy is a validated methodology to obtain circulating tumour components such as circulating tumour DNA (ctDNA) and circulating tumour cells (CTCs) from body fluids in an easy-to-perform minimal-invasive manner. However, its clinical validity in cancer is still to be demonstrated. This review focusses on the utilisation of both ctDNA and CTCs in early and metastatic HER2-positive BC tumours. We discuss recently published studies deciphering the capacity of liquid biopsy to determine the response to neoadjuvant and adjuvant therapies as well as to predict patients' outcomes. 10.3390/cancers14030587 2072-6694 Cancers http://hdl.handle.net/10668/20870 35158855 http://hdl.handle.net/20.500.12105/18586 HER2-positive breast cancer circulating-tumour DNA circulating-tumour cells early breast cancer liquid biopsy metastatic breast cancer Unveiling the Potential of Liquid Biopsy in HER2-Positive Breast Cancer Management.