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oai:repisalud.isciii.es:20.500.12105/185692024-10-04T08:01:04Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16960col_20.500.12105_16967

00925njm 22002777a 4500 dc Lopes, Luis R author Losi, Maria-Angela author Sheikh, Nabeel author Laroche, Cécile author Charron, Philippe author Gimeno, Juan author Kaski, Juan P author Maggioni, Aldo P author Tavazzi, Luigi author Arbustini, Eloisa author Brito, Dulce author Celutkiene, Jelena author Hagege, Albert author Linhart, Ales author Mogensen, Jens author Garcia-Pinilla, José Manuel author Ripoll-Vera, Tomas author Seggewiss, Hubert author Villacorta, Eduardo author Caforio, Alida author Elliott, Perry M author Cardiomyopathy Registry Investigators Group author 2022 Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits. Lopes LR, Losi M-A, Sheikh N, Laroche C, Charron P, Gimeno J, et al. Association Between Common Cardiovascular Risk Factors and Clinical Phenotype in Patients with Hypertrophic Cardiomyopathy From the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis Registry. Eur Hear journal Qual care Clin outcomes. 9 febrer 2022. 10.1093/ehjqcco/qcac006 2058-1742 European heart journal. Quality of care & clinical outcomes http://hdl.handle.net/10668/19763 http://hdl.handle.net/20.500.13003/18075 35138368 http://hdl.handle.net/20.500.12105/18569 791185100001 Cardiovascular risk factors Diabetes Genotype Hypertension Hypertrophic cardiomyopathy Obesity Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry