2026-04-29T06:16:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185612024-09-21T21:59:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Maniglier, Madlyne
author
Vidal, Marie
author
Bachelin, Corinne
author
Deboux, Cyrille
author
Chazot, Jérémy
author
Garcia-Diaz, Beatriz
author
Baron-Van Evercooren, Anne
2024-02-27T14:57:28Z
2024-02-27T14:57:28Z
2022
http://hdl.handle.net/10668/22526
http://hdl.handle.net/20.500.12105/18561
36351367
10.1016/j.stemcr.2022.10.002
2213-6711
Stem cell reports
The presence of putative stem/progenitor cells has been suggested in adult peripheral nervous system (PNS) tissue, including the dorsal root ganglion (DRG). To date, their identification and fate in pathophysiological conditions have not been addressed. Combining multiple in vitro and in vivo approaches, we identified the presence of stem cells in the adult DRG satellite glial population, and progenitors were present in the DRGs and sciatic nerve. Cell-specific transgenic mouse lines highlighted the proliferative potential of DRG stem cells and progenitors in vitro. DRG stem cells had gliogenic and neurogenic potentials, whereas progenitors were essentially gliogenic. Lineage tracing showed that, under physiological conditions, adult DRG stem cells maintained DRG homeostasis by supplying satellite glia. Under pathological conditions, adult DRG stem cells replaced DRG neurons lost to injury in addition of renewing the satellite glial pool. These novel findings open new avenues for development of therapeutic strategies targeting DRG stem cells for PNS disorders.
eng
CNS
DRG
injury
peripheral nerve
satellite glial cells
spinal cord
stem cells
Satellite glia of the adult dorsal root ganglia harbor stem cells that yield glia under physiological conditions and neurons in response to injury.
research article