2026-06-04T18:49:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185352024-11-29T20:38:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Whittemore, Kurt
author
Vera, Elsa
author
Martínez-Nevado, Eva
author
Sanpera, Carola
author
Blasco, MA
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Botín Foundation
funder
World Cancer Research Fund International
2024-02-20T13:13:58Z
2024-02-20T13:13:58Z
2019-07-23
Proc Natl Acad Sci U S A. 2019 ;116(30):15122-15127.
10.1073/pnas.1902452116
1091-6490
Proceedings of the National Academy of Sciences of the United States of America
31285335
http://hdl.handle.net/20.500.12105/18535
Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA damage response at chromosome ends and loss of cellular viability. However, whether telomere length is a universal determinant of species longevity is not known. To determine whether telomere shortening can be a single parameter to predict species longevities, here we measured in parallel the telomere length of a wide variety of species (birds and mammals) with very different life spans and body sizes, including mouse (Mus musculus), goat (Capra hircus), Audouin's gull (Larus audouinii), reindeer (Rangifer tarandus), griffon vulture (Gyps fulvus), bottlenose dolphin (Tursiops truncatus), American flamingo (Phoenicopterus ruber), and Sumatran elephant (Elephas maximus sumatranus). We found that the telomere shortening rate, but not the initial telomere length alone, is a powerful predictor of species life span. These results support the notion that critical telomere shortening and the consequent onset of telomeric DNA damage and cellular senescence are a general determinant of species life span.
eng
Telomere shortening rate predicts species life span.
journal article
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URL
https://repisalud.isciii.es/bitstreams/0e0e5b44-9e87-4b77-b554-50b542e79cd4/download
File
MD5
60bafe1300c3e3de0e94ac9a11aaceb6
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application/pdf
Telomereshorteningrate_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/d1e66a5b-9d18-4ffe-b471-65a97f16d9e6/download
File
MD5
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text/plain
Telomereshorteningrate_2019.pdf.txt