2026-06-14T03:32:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185332024-11-29T13:58:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Whittemore, Kurt
author
Martínez-Nevado, Eva
author
Blasco, MA
funder
Botín Foundation
funder
Ministerio de Ciencia, Innovación y Universidades (España)
2024-02-20T12:42:39Z
2024-02-20T12:42:39Z
2019-11-15
Aging (Albany NY) . 2019 ;11(21):9829-9845.
10.18632/aging.102430
1945-4589
Aging
31730540
http://hdl.handle.net/20.500.12105/18533
Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phylogenetically distinct species from birds to mammals was lacking. Here, we demonstrate that the rate of accumulation of DNA damage as measured by the DNA damage marker γH2AX correlates with species longevity in dolphins, goats, reindeer, American flamingos, and griffon vultures. In particular, we find that species that show slower rates of accumulation of the DNA damage marker γH2AX also live longer.
eng
Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.
journal article
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URL
https://repisalud.isciii.es/bitstreams/1dfae69d-d428-4c87-a72b-713c295f9785/download
File
MD5
80af774c94f835c03584806e5691b561
3101199
application/pdf
SlowerratesofaccumulationofDNA_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/9651ff16-c155-4b4b-bb63-d5bd71629ee6/download
File
MD5
50c9b00e2dbb33edafb3734c155ad400
52761
text/plain
SlowerratesofaccumulationofDNA_2019.pdf.txt