2026-06-14T03:35:55Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/185332024-11-29T13:58:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Whittemore, Kurt author Martínez-Nevado, Eva author Blasco, MA author 2019-11-15 Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phylogenetically distinct species from birds to mammals was lacking. Here, we demonstrate that the rate of accumulation of DNA damage as measured by the DNA damage marker γH2AX correlates with species longevity in dolphins, goats, reindeer, American flamingos, and griffon vultures. In particular, we find that species that show slower rates of accumulation of the DNA damage marker γH2AX also live longer. Aging (Albany NY) . 2019 ;11(21):9829-9845. 10.18632/aging.102430 1945-4589 Aging 31730540 http://hdl.handle.net/20.500.12105/18533 Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.