2026-06-14T03:39:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185262024-09-21T23:18:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Peinado, María Ángeles
author
Ovelleiro, David
author
Del Moral, María Luisa
author
Hernández, Raquel
author
Martínez-Lara, Esther
author
Siles, Eva
author
Pedrajas, José Rafael
author
García-Martín, María Luisa
author
Caro, Carlos
author
Peralta, Sebastián
author
Morales, María Encarnación
author
Ruiz, María Adolfina
author
Blanco, Santos
2024-02-19T15:32:34Z
2024-02-19T15:32:34Z
2021-12-27
10.3390/ijms23010247
1422-0067
International journal of molecular sciences
http://hdl.handle.net/10668/21127
35008673
http://hdl.handle.net/20.500.12105/18526
Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value
eng
MCAO
hyaluronate nanoparticles
neuroglobin
neuroprotection
proteomics
stroke
Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
research article