2026-06-14T03:44:26Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/185262024-09-21T23:18:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Peinado, María Ángeles author Ovelleiro, David author Del Moral, María Luisa author Hernández, Raquel author Martínez-Lara, Esther author Siles, Eva author Pedrajas, José Rafael author García-Martín, María Luisa author Caro, Carlos author Peralta, Sebastián author Morales, María Encarnación author Ruiz, María Adolfina author Blanco, Santos author 2021-12-27 Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value 10.3390/ijms23010247 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/21127 35008673 http://hdl.handle.net/20.500.12105/18526 MCAO hyaluronate nanoparticles neuroglobin neuroprotection proteomics stroke Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.