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00925njm 22002777a 4500 dc Díaz Del Moral, Sandra author Benaouicha, Maha author Muñoz-Chápuli, Ramón author Carmona, Rita author 2021-12-26 Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the Igf1r and the insulin receptor (Insr) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart. http://hdl.handle.net/10668/21126 http://hdl.handle.net/20.500.12105/18524 35008660 10.3390/ijms23010234 1422-0067 International journal of molecular sciences heart development insulin-like growth factor receptors insulin-like growth factors myocardial proliferation The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration.