2026-04-29T04:09:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185182024-11-28T14:44:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
De La Cruz Cortés, José Pedro
author
Vallejo-Carmona, Leticia
author
Arrebola, María Monsalud
author
Martín-Aurioles, Esther
author
Rodriguez-Pérez, María Dolores
author
Ortega-Hombrados, Laura
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Verdugo, Cristina
author
Fernández-Prior, María África
author
Bermúdez-Oria, Alejandra
author
González-Correa, José Antonio
authoraffiliation
[De La Cruz Cortés,JP; Rodriguez-Pérez,MD; Ortega-Hombrados,L; Verdugo,C; González-Correa,JA] Departmento de Farmacología, Instituto de Investigación Biomédica (IBIMA), Facultad de Medicina, Universidad de Málaga, Málaga, Spain. [Vallejo-Carmona,L] Facultad de Enfermería, Universidad Ana G. Mendez, Recinto Cupei, San Juan, Puerto Rico. [Arrebola,MM] UGC Laboratorio Clínico, Hospital de la Axarquía, AGSEMA, Málaga, Spain. [Martín-Aurioles,E] Distrito Sanitario Málaga-Guadalhorce, UGC La Roca, Málaga, Spain. [Fernández-Prior,MÁ; Bermúdez-Oria,A] Consejo Superior de Investigaciones Científicas (CSIC), Instituto de la Grasa, Seville, Spain.
2024-02-19T15:32:22Z
2024-02-19T15:32:22Z
2021-12-13
http://hdl.handle.net/10668/4325
http://hdl.handle.net/20.500.12105/18518
34943086
10.3390/antiox10121983
2076-3921
Antioxidants
The objective of this study was to assess a possible synergistic effect of two extra-virgin olive oil polyphenols, 3,4,-dyhydroxyphenylglycol (DHPG) and hydroxytyrosol (HT), in an experimental model of type 1 diabetes. Seven groups of animals were studied: (1) Nondiabetic rats (NDR), (2) 2-month-old diabetic rats (DR), (3) DR treated with 5 mg/kg/day p.o. HT, (4) DR treated with 0.5 mg/kg/day p.o. DHPG, (5) DR treated with 1 mg/kg/day p.o. DHPG, (6) DR treated with HT + DHPG (0.5), (7) DR treated with HT + DHPG (1). Oxidative stress variables (lipid peroxidation, glutathione, total antioxidant activity, 8-isoprostanes, 8-hydroxy-2-deoxyguanosine, and oxidized LDL), nitrosative stress (3-nitrotyrosine), and some cardiovascular biomarkers (platelet aggregation, thromboxane B2, prostacyclin, myeloperoxidase, and vascular cell adhesion protein 1 (VCAM-1)) were analyzed. The diabetic animals showed an imbalance in all of the analyzed variables. HT exerted an antioxidant and downregulatory effect on prothrombotic biomarkers while reducing the fall of prostacyclin. DHPG presented a similar, but quantitatively lower, profile. HT plus DHPG showed a synergistic effect in the reduction of oxidative and nitrosative stress, platelet aggregation, production of prostacyclin, myeloperoxidase, and VCAM-1. This synergism could be important for the development of functional oils enriched in these two polyphenols in the proportion used in this study.
eng
Hydroxytyrosol
Extra-virgin olive oil polyphenols
3',4' -dihidroxifenilglicol
Oxidative stress
Cardiovascular
Polifenoles
Aceite de oliva
Estrés oxidativo
Estrés nitrosativo
Biomarcadores
Diabetes mellitus tipo 1
Synergistic Effect of 3',4'-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus
research article