2026-06-14T03:40:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185132024-11-28T14:48:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Cornejo-Pareja, Isabel
author
Ramirez, Maria
author
Camprubi-Robles, Maria
author
Rueda, Ricardo
author
Vegas-Aguilar, Isabel Maria
author
Garcia-Almeida, Jose Manuel
authoraffiliation
[Cornejo-Pareja,I; Vegas-Aguilar,IM; Garcia-Almeidam,JM] Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, Malaga, Spain. [Cornejo-Pareja,I; Vegas-Aguilar,IM; Garcia-Almeidam,JM] Centro de Investigacion Biomedica en Red de la Fisiopatología de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Malaga, Spain. [Ramirez,M; Camprubi-Robles,M; Rueda,R] Abbott Nutrition, Research and Development, Granada, Spain.
2024-02-19T15:32:17Z
2024-02-19T15:32:17Z
2021-12-03
10.3390/nu13124355
2072-6643
Nutrients
http://hdl.handle.net/10668/4358
34959907
http://hdl.handle.net/20.500.12105/18513
This is a retrospective study of data from clinical practice to observe the effect of a high-calorie, high-protein oral nutritional supplement (ONS) with β-hydroxy-β-methylbutyrate (HMB) on nutritional status, body weight, and muscle-related parameters in 283 adult patients with or at risk of malnutrition under standard of care, 63% being cancer patients. They were recommended to increase physical activity and energy and protein intake from regular diet plus two servings per day of a specialized ONS enriched with HMB or standard ONS for up to 6 months. Dietary records, adherence and tolerance to ONS, nutritional status, body composition, handgrip strength, and blood analysis at the beginning and the end of the intervention were recorded. This program improved nutritional status from 100% malnourished or at risk of malnutrition at baseline to 80% well-nourished at final visit. It also increased body weight by 3.6-3.8 kg, fat-free mass by 0.9 to 1.3 kg, and handgrip strength by 4.7 to 6.2 kg. In a subgroup of patients (n = 43), phase angle (PhA), and body cell mass (BCM) increased only in the patients receiving the ONS enriched with HMB (0.95 (0.13) vs. -0.36 (0.4), and 2.98 (0.5) vs. -0.6 (1.5) kg, mean difference (SE) from baseline for PhA and BCM, respectively), suggesting the potential efficacy of this supplement on muscle health.
eng
Malnutrition
Muscle loss
Oral nutritional supplements
Cancer
β-hydroxy-β-methylbuty rate
Phase angle
Body cell mass
Nutritional status
Body composition
Body weight
Vitamin D
Desnutrición
Músculos
Suplementos dietéticos
Neoplasias
Estado nutricional
Composición corporal
Peso corporal
Vitamina D
Effect on an Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate and Vitamin D on Morphofunctional Aspects, Body Composition, and Phase Angle in Malnourished Patients
research article