2026-06-14T03:44:43Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/185132024-11-28T14:48:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Cornejo-Pareja, Isabel author Ramirez, Maria author Camprubi-Robles, Maria author Rueda, Ricardo author Vegas-Aguilar, Isabel Maria author Garcia-Almeida, Jose Manuel author 2021-12-03 This is a retrospective study of data from clinical practice to observe the effect of a high-calorie, high-protein oral nutritional supplement (ONS) with β-hydroxy-β-methylbutyrate (HMB) on nutritional status, body weight, and muscle-related parameters in 283 adult patients with or at risk of malnutrition under standard of care, 63% being cancer patients. They were recommended to increase physical activity and energy and protein intake from regular diet plus two servings per day of a specialized ONS enriched with HMB or standard ONS for up to 6 months. Dietary records, adherence and tolerance to ONS, nutritional status, body composition, handgrip strength, and blood analysis at the beginning and the end of the intervention were recorded. This program improved nutritional status from 100% malnourished or at risk of malnutrition at baseline to 80% well-nourished at final visit. It also increased body weight by 3.6-3.8 kg, fat-free mass by 0.9 to 1.3 kg, and handgrip strength by 4.7 to 6.2 kg. In a subgroup of patients (n = 43), phase angle (PhA), and body cell mass (BCM) increased only in the patients receiving the ONS enriched with HMB (0.95 (0.13) vs. -0.36 (0.4), and 2.98 (0.5) vs. -0.6 (1.5) kg, mean difference (SE) from baseline for PhA and BCM, respectively), suggesting the potential efficacy of this supplement on muscle health. 10.3390/nu13124355 2072-6643 Nutrients http://hdl.handle.net/10668/4358 34959907 http://hdl.handle.net/20.500.12105/18513 Malnutrition Muscle loss Oral nutritional supplements Cancer β-hydroxy-β-methylbuty rate Phase angle Body cell mass Nutritional status Body composition Body weight Vitamin D Desnutrición Músculos Suplementos dietéticos Neoplasias Estado nutricional Composición corporal Peso corporal Vitamina D Effect on an Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate and Vitamin D on Morphofunctional Aspects, Body Composition, and Phase Angle in Malnourished Patients