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oai:repisalud.isciii.es:20.500.12105/185072024-11-28T14:43:13Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Jansen-Chaparro, Sergio author López-Carmona, María D. author Cobos-Palacios, Lidia author Sanz-Cánovas, Jaime author Bernal-López, M. Rosa author Gómez-Huelgas, Ricardo author 2021-11-22 Peripheral arterial disease (PAD) is a highly prevalent atherosclerotic condition. In patients with PAD, the presence of intermittent claudication leads to a deterioration in quality of life. In addition, even in asymptomatic cases, patients with PAD are at high risk of cardiac or cerebrovascular events. Treatment of PAD is based on lifestyle modifications; regular exercise; smoking cessation; and control of cardiovascular risk factors, including hypercholesterolemia. A growing number of studies have shown that statins reduce cardiovascular risk and improve symptoms associated with PAD. Current guidelines recommend the use of statins in all patients with PAD in order to decrease cardiovascular events and mortality. However, the prescribing of statins in patients with PAD is lower than in those with coronary heart disease. This review provides relevant information from the literature that supports the use of statins in patients with PAD and shows their potential benefit in decreasing lower limb complications as well as cardiovascular morbidity and mortality. 10.3389/fcvm.2021.777016 2297-055X Frontiers in Cardiovascular Medicine http://hdl.handle.net/10668/4201 34881314 http://hdl.handle.net/20.500.12105/18507 Statins Peripheral arterial disease Cardiovascular risk Amputation Critical limb ischemia Intermittent claudication Hypercholesterolemia Coronary heart disease Inhibidores de hidroximetilglutaril-CoA reductasas Enfermedad arterial periférica Factores de riesgo de enfermedad cardiaca Amputación Isquemia crónica que amenaza las extremidades Claudicación intermitente Hipercolesterolemia Enfermedad coronaria Statins and Peripheral Arterial Disease: A Narrative Review