2026-04-29T00:59:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/185022024-11-28T15:46:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Martínez-Montoro, José Ignacio
author
Cornejo-Pareja, Isabel
author
Gómez-Pérez, Ana María
author
Tinahones, Francisco J.
authoraffiliation
[Martínez-Montoro,JI; Gómez-Pérez,AM; Tinahones,FJ] Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain. [Martínez-Montoro,JI; Tinahones,FJ] Faculty of Medicine, University of Málaga, Málaga, Spain. [Cornejo-Pareja,I; Tinahones,FJ] Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria University Hospital, Málaga, Spain. [Tinahones,FJ] Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.
2024-02-19T15:32:00Z
2024-02-19T15:32:00Z
2021-11-15
http://hdl.handle.net/10668/3642
http://hdl.handle.net/20.500.12105/18502
34836332
10.3390/nu13114077
2072-6643
Nutrients
In the last decades, the global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached pandemic proportions with derived major health and socioeconomic consequences; this tendency is expected to be further aggravated in the coming years. Obesity, insulin resistance/type 2 diabetes mellitus, sedentary lifestyle, increased caloric intake and genetic predisposition constitute the main risk factors associated with the development and progression of the disease. Importantly, the interaction between the inherited genetic background and some unhealthy dietary patterns has been postulated to have an essential role in the pathogenesis of NAFLD. Weight loss through lifestyle modifications is considered the cornerstone of the treatment for NAFLD and the inter-individual variability in the response to some dietary approaches may be conditioned by the presence of different single nucleotide polymorphisms. In this review, we summarize the current evidence on the influence of the association between genetic susceptibility and dietary habits in NAFLD pathophysiology, as well as the role of gene polymorphism in the response to lifestyle interventions and the potential interaction between nutritional genomics and other emerging therapies for NAFLD, such as bariatric surgery and several pharmacologic agents.
eng
Non-alcoholic fatty liver disease
Gene polymorphismc
Dietary intervention
Gene-nutrient interactions
Bariatric surgery
Pharmacotherapy
Enfermedad del hígado graso no alcohólico
Polimorfismo genético
Genes nutrientes
Cirugía bariátrica
Quimioterapia
Hígado graso
Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
review article