2026-04-29T07:22:53Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184992024-11-28T15:17:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Rodríguez-Pérez, María Dolores
author
López-Villodres, Juan Antonio
author
Arrebola, María Monsalud
author
Martín-Aurioles, Esther
author
Fernández-Prior, África
author
Bermúdez-Oria, Alejandra
author
Ríos, María Carmen
author
De La Cruz, José Pedro
author
González-Correa, José Antonio
authoraffiliation
[Rodríguez-Pérez,MD; De La Cruz,JP; González-Correa,JA] Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, Málaga, Spain. [López-Villodres,JA; Ríos,MC] Area of Human Histology, Faculty of Medicine, University of Malaga, Málaga, Spain. [Arrebola,MM] Clinical Laboratory, Clinical Management Unit, Hospital Axarquía, AGSEMA, Málaga, Spain. [Martín-Aurioles,E] Clinical Management Unit La Roca, Distrito Sanitario, AGSEMA, Málaga, Spain. [Fernández-Prior,A; Bermúdez-Oria,A] Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Seville, Spain.
2024-02-19T15:31:57Z
2024-02-19T15:31:57Z
2021-11-08
http://hdl.handle.net/10668/4338
http://hdl.handle.net/20.500.12105/18499
34829654
10.3390/antiox10111783
2076-3921
Antioxidants
The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.
eng
Hydroxytyrosol
Diabetes
Nephropathy
Virgin olive oil
Diabetes mellitus
Creatinine
Oxidative stress
Proteinuria
Thromboxane
Eicosanoids
Nefropatías diabéticas
Aceite de oliva
Creatinina
Estrés oxidativo
Tromboxanos
Eicosanoides
Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
research article