2026-04-29T07:23:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184992024-11-28T15:17:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Rodríguez-Pérez, María Dolores author López-Villodres, Juan Antonio author Arrebola, María Monsalud author Martín-Aurioles, Esther author Fernández-Prior, África author Bermúdez-Oria, Alejandra author Ríos, María Carmen author De La Cruz, José Pedro author González-Correa, José Antonio author 2021-11-08 The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production. http://hdl.handle.net/10668/4338 http://hdl.handle.net/20.500.12105/18499 34829654 10.3390/antiox10111783 2076-3921 Antioxidants Hydroxytyrosol Diabetes Nephropathy Virgin olive oil Diabetes mellitus Creatinine Oxidative stress Proteinuria Thromboxane Eicosanoids Nefropatías diabéticas Aceite de oliva Creatinina Estrés oxidativo Tromboxanos Eicosanoides Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect