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oai:repisalud.isciii.es:20.500.12105/184962024-11-28T15:22:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16980col_20.500.12105_16987

00925njm 22002777a 4500 dc Muñoz, Gerard author de Gracia, Javier author Giron, Rosa author Olveira, Casilda author Alvarez, Antonio author Buxó, Maria author Birring, Surinder S. author Vendrell, Montserrat author 2021-11-03 Cough is a main symptom in cystic fibrosis (CF). We aim to validate a Spanish version of the Leicester Cough Questionnaire (LCQ-Sp) to measure the impact of cough in CF bronchiectasis. A prospective longitudinal multicentre study was performed. Internal consistency and score changes over a 15-day period in stable state were assessed to analyse reliability. Concurrent validity was analysed by correlation with Saint George's Respiratory Questionnaire (SGRQ) and convergent validity by assessing the association with clinical variables. Changes in scores between stable state and the first exacerbation were assessed to analyse responsiveness. 132 patients (29.73 ± 10.52 years) were enrolled in four hospitals. Internal consistency was high for the total score and good for the three domains (Cronbach's α 0.81-0.93). The test-retest reliability showed an intraclass correlation coefficient of 0.86 for the total score. The correlation between LCQ-Sp and SGRQ scores was -0.74. The LCQ-Sp score negatively correlated with sputum volume, and the mean score decreased at the beginning of exacerbations (16.04±3.81 vs 13.91±4.29) with a large effect size. The LCQ-Sp is a reliable, repeatable and responsive instrument to assess the impact of cough in CF bronchiectasis and is responsive to change in the event of exacerbations. 10.1177/14799731211036903 1479-9731 1479-9723 Chronic Respiratory Disease http://hdl.handle.net/10668/4561 34730449 http://hdl.handle.net/20.500.12105/18496 Cystic fibrosis Cough Quality of life Bronchiectasis Symptoms Respiratory disease Sputum Fibrosis quística Tos Calidad de vida Bronquiectasia Enfermedades respiratorias Esputo Validation of a Spanish version of the Leicester Cough Questionnaire in cystic fibrosis