2026-04-26T23:19:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184922024-11-28T15:18:13Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Caballero, Abelardo
author
Vazquez-Sanchez, Teresa
author
Ruiz-Esteban, Pedro
author
Leon, Myriam
author
Alonso-Titos, Juana
author
Lopez, Veronica
author
Sola, Eugenia
author
Gutierrez, Elena
author
Cabello, Mercedes
author
Casas-Gonzalez, Cristina
author
Pozo-Alvarez, Rafael
author
Delgado-Burgos, Juan
author
Hernandez, Domingo
authoraffiliation
[Caballero,A] Immunology Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Malaga, Spain. [Vazquez-Sanchez,T; Ruiz-Esteban,P; Alonso-Titos,J; Lopez,V; Sola,E; Gutierrez,E; Cabello,M; Casas-Gonzalez,C; Pozo-Alvarez,R; Delgado-Burgos,J; Hernandez,D] Nephrology Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Malaga, Spain. [Leon,M] Pathology Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Malaga, Spain.
2024-02-19T15:31:50Z
2024-02-19T15:31:50Z
2021-10-28
http://hdl.handle.net/10668/4247
http://hdl.handle.net/20.500.12105/18492
34768571
10.3390/jcm10215051
2077-0383
Journal of Clinical Medicine
We determined the association between CD14++CD16+ monocytes and subclinical infiltrates that do not reach the histological threshold for rejection (≥Banff IA). We studied low-immunological-risk kidney-transplant recipients in a clinical trial (NCT02284464; EudraCT 2012-003298-24) whose protocol biopsy in the third month showed no significant changes or borderline lesions (BL). Flow cytometry was used to analyze the percentage of CD14++CD16+ monocytes in peripheral blood (PB) and blood from a fine-needle-aspiration biopsy (FNAB). A protocol biopsy was performed in 81 low-immunological-risk patients, of whom 15 were excluded (BK polyomavirus and rejection). The 28 (42.4%) with borderline lesions had significantly low levels of CD14++CD16+ in PB compared to patients with normal biopsies (7.9 ± 5.4 vs. 13.0 ± 12.8; p = 0.047). Patients without significant changes had similar percentages of CD14++CD16+ monocytes in the graft blood (GB) and FNAB blood. The percentage of these monocytes in the patients with an interstitial infiltrate, however, increased significantly in the FNAB blood compared to the GB: 16.9 ± 16.6 vs. 7.9 ± 5.4; p = 0.006. A difference of 50% in CD14++CD16+ in the GB versus the PB was a significant risk factor (p = 0.002) for BL, increasing the risk seven times. A decrease in CD14++CD16+ in the PB could be associated with the recruitment of these cells to the graft tissue in cases of subclinical BL inflammatory infiltrates below the threshold for rejection.
eng
Kidney transplant
Monocytes
CD14++CD16+
Kidney biopsy
Borderline lesions
Transplants
Riñón
Monocitos
Receptores de lipopolisacáridos
Receptores de IgG
Biopsia
Lesión renal aguda
Decrease in CD14++CD16+ Monocytes in Low-Immunological-Risk Kidney Transplant Patients with Subclinical Borderline Inflammation
research article