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oai:repisalud.isciii.es:20.500.12105/184902024-11-28T15:23:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Ocaña-Wilhelmi, Luis author Martín-Núñez, Gracia María author Ruiz-Limón, Patricia author Alcaide, Juan author García-Fuentes, Eduardo author Gutiérrez-Repiso, Carolina author Tinahones, Francisco J. author Moreno-Indias, Isabel authoraffiliation [Ocaña-Wilhelmi,L] Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Universidad de Málaga, Málaga, Spain. [Ocaña-Wilhelmi,L] Unidad de Gestión Clínica de Cirugía General y del Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Martín-Núñez,GM; , Ruiz-Limón,P; Alcaide,J; Gutiérrez-Repisom,C; Tinahones,FJ; Moreno-Indias,I] Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga University, Málaga, Spain. [Martín-Núñez,GM; , Ruiz-Limón,P; Alcaide,J; Gutiérrez-Repisom,C; Tinahones,FJ; Moreno-Indias,I] Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [García-Fuentes,E] Department of Gastroenterology, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Málaga (IBIMA), Málaga University, Málaga, Spain. [García-Fuentes,E] CIBER Enfermedades Hepáticas y Digestivas-CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain. 2024-02-19T15:31:49Z 2024-02-19T15:31:49Z 2021-10-27 http://hdl.handle.net/10668/4283 http://hdl.handle.net/20.500.12105/18490 34822391 10.3390/metabo11110733 2218-1989 Metabolites Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In the current study, we have compared the gut microbiota and the bile acid pool, as well as anthropometric and biochemical parameters, of patient with morbid obesity who underwent bariatric surgery by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Gut microbiota populations differed after the respective procedures, particularly with respect to the Enterobacteriaceae family. Both techniques resulted in changes in the bile acids pool, but RYGB was the procedure which suffered the greatest changes, with a reduction in most of their levels. Blautia and Veillonella were the two genera that more relationships showed with secondary bile acids, indicating a possible role in their formation and inhibition, respectively. Correlations with the anthropometric and biochemical variables showed that secondary bile acids could have a role in the amelioration of the glucose and HDL-cholesterol levels. Thus, we have observed a possible relationship between the interaction of the bile acids pool metabolized by the gut microbiota in the metabolic improvements obtained by bariatric surgery in the frame of morbid obesity, deserving further investigation in greater cohorts to decipher the role of each bile acid in the homeostasis of the host for their possible use in the development of microbiota-based therapeutics, such as new drugs, postbiotics or probiotics. eng Bile acids Bariatric surgery Gut microbiota Enterobacteriaceae Ácidos y sales biliares Cirugía bariátrica Microbioma gastrointestinal Probióticos Obesidad Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity research article