2026-07-21T14:15:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184852024-11-28T15:24:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Pérez-Ruiz, Elisabeth
author
Gutiérrez, Vanesa
author
Muñoz, Marta
author
Oliver, Javier
author
Sánchez, Marta
author
Gálvez-Carvajal, Laura
author
Rueda-Domínguez, Antonio
author
Barragán, Isabel
authoraffiliation
[Pérez-Ruiz,E; Gutiérrez,V; Muñoz,M; Gálvez-Carvajal,L; Rueda-Domínguez,A] Unidad de Gestión Clínica Intercentros de Oncología Médica, Oncology Department, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Oliver,J; Barragán,I] Researcher Unit, Unidad de Gestión Clínica Intercentros de Oncología Médica, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Sánchez,M] Maxillofacial Surgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain. [Barragán,I] Group of Pharmacoepigenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
2024-02-19T15:31:44Z
2024-02-19T15:31:44Z
2021-10-15
10.3390/biomedicines9101478
2227-9059
Biomedicines
http://hdl.handle.net/10668/4333
34680596
http://hdl.handle.net/20.500.12105/18485
Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.
eng
Oral cell carcinoma
Field cancerization
Liquid biopsy
Tobacco
Saliva
Early diagnosis
Carcinoma de células escamosas de cabeza y cuello
Biopsia líquida
Tabaco
Diagnóstico precoz
Detección precoz del cáncer
Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
review article