2026-06-14T03:31:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184802024-11-28T15:34:12Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
García-Casares, Natalia
author
Gallego Fuentes, Paloma
author
Barbancho, Miguel Ángel
author
López-Gigosos, Rosa
author
García-Rodríguez, Antonio
author
Gutiérrez-Bedmar, Mario
authoraffiliation
[García-Casares,N; Gallego Fuentes,P; Barbancho,MÁ; López-Gigosos,R; García-Rodríguez,A; Gutiérrez-Bedmar,M] School of Medicine, University of Málaga, Málaga, Spain. [García-Casares,N; Barbancho,MÁ] Centro de Investigaciones Médico-Sanitarias (CIMES), University of Málaga, Málaga, Spain. [García-Casares,N; Barbancho,MÁ; López-Gigosos,R; García-Rodríguez,A; Gutiérrez-Bedmar,M] Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Gutiérrez-Bedmar,M] CIBERCV Cardiovascular Diseases, Carlos III Health Institute, Madrid, Spain.
2024-02-19T15:31:40Z
2024-02-19T15:31:40Z
2021-10-10
10.3390/jcm10204642
2077-0383
Journal of Clinical Medicine
http://hdl.handle.net/10668/4326
34682764
http://hdl.handle.net/20.500.12105/18480
Alzheimer's Disease (AD) is a pathology with increasing prevalence in the context of a more long-lived society and it is the first cause of dementia in western countries. It is important to investigate factors that can be protective and may influence its development, in order to act on them trying to reduce AD incidence and its progression. The aim of this study was to conduct a systematic review and meta-analysis to determine the effects of a higher adherence to Mediterranean diet (MD) on Mild Cognitive Impairment (MCI) and AD. A literature search in PubMed, The Cochrane Library Plus and Scopus was conducted, selecting articles that analyzed associations between MD adherence and AD biomarkers (Volumetry assessed by MRI and betamiloide and Tau deposits by PET); cognitive performance in patients at risk or presenting MCI and AD; and incidence or progression from MCI to AD. Out of the 589 studies screened, 22 studies met eligibility criteria for the systematic review and qualitative synthesis. Finally, 11 studies were included in the meta-analysis (12,458 participants). Higher adherence to MD was associated with a significantly lower risk of MCI (RR = 0.91, 95%CI = 0.85-0.97) and lower risk of AD (RR = 0.89, 95% CI = 0.84-0.93). Our results enhance the importance of taking health-promoting lifestyle measures like following Mediterranean dietary patterns in order to reduce AD risk.
eng
Mediterranean diet
Alzheimer’s disease
Mild cognitive impairment
Meta-analysis
Dieta mediterránea
Enfermedad de Alzheimer
Disfunción cognitiva
Metaanálisis
Revisión sistemática
Alzheimer's Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis
review article