2026-08-05T15:04:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184792024-11-28T15:00:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Cárdenas, Casimiro
author
Torres-Vargas, José Antonio
author
Cárdenas-Valdivia, Abel
author
Jurado, Nuria
author
Quesada, Ana R.
author
García-Caballero, Melissa
author
Martínez-Poveda, Beatriz
author
Medina, Miguel Ángel
authoraffiliation
[Cárdenas,C; Torres-Vargas,JA; Jurado,N; Quesada,AR; García-Caballero,M; Martínez-Poveda,B; Medina,MÁ] Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Málaga, Spain. [Cárdenas,C] Research Support Central Services (SCAI) of the University of Málaga, Spain. [Torres-Vargas,JA; Quesada,AR; García-Caballero,M; Martínez-Poveda,B; Medina,MÁ] IBIMA (Biomedical Research Institute of Málaga), Málaga, Spain. [Cárdenas-Valdivia,A] Department of Physical Chemistry, Faculty of Sciences, University of Malaga, Malaga, Spain. [Quesada,AR; Medina,MÁ] CIBER de Enfermedades Raras (CIBERER), Málaga, Spain. [Martínez-Poveda,B] CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
2024-02-19T15:31:40Z
2024-02-19T15:31:40Z
2021-10-06
10.1016/j.biopha.2021.112263
1950-6007
0753-3322
Biomedicine & Pharmacotherapy
http://hdl.handle.net/10668/4594
34626933
http://hdl.handle.net/20.500.12105/18479
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
eng
Ultra-high-performance liquid
Chromatography-high-resolution mass spectrometry (UHPLC–HRMS)
Annona muricata
Graviola
Soursop
Angiogenesis
Cromatografía líquida de alta presión
Espectrometría de masas
Annonaceae
Annona
Neovascularización fisiológica
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
research article