2026-08-05T15:04:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184792024-11-28T15:00:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Cárdenas, Casimiro author Torres-Vargas, José Antonio author Cárdenas-Valdivia, Abel author Jurado, Nuria author Quesada, Ana R. author García-Caballero, Melissa author Martínez-Poveda, Beatriz author Medina, Miguel Ángel author 2021-10-06 The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds. 10.1016/j.biopha.2021.112263 1950-6007 0753-3322 Biomedicine & Pharmacotherapy http://hdl.handle.net/10668/4594 34626933 http://hdl.handle.net/20.500.12105/18479 Ultra-high-performance liquid Chromatography-high-resolution mass spectrometry (UHPLC–HRMS) Annona muricata Graviola Soursop Angiogenesis Cromatografía líquida de alta presión Espectrometría de masas Annonaceae Annona Neovascularización fisiológica Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity