2026-08-29T13:36:49Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184632024-02-19T15:31:02Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16971

00925njm 22002777a 4500 dc Flores-López, María author García-Marchena, Nuria author Pavon, Francisco Javier author Lara, Estrella author Porras-Perales, Oscar author Araos, Pedro author Requena-Ocaña, Nerea author Torres-Galván, Sandra author Mañas-Padilla, M Carmen author Rubio, Gabriel author Suárez, Juan author Santín, Luis J author Rodríguez de Fonseca, Fernando author Castilla-Ortega, Estela author García-Fernández, María I author Serrano, Antonia author 2021-09-13 Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX-LPA axis has been associated with cognitive dysfunction and inflammatory diseases, mainly in a range of nonalcoholic liver diseases. Recently, preclinical and clinical evidence has suggested a role of LPA signaling in alcohol use disorder (AUD) and AUD-related cognitive function. However, the ATX-LPA axis has not been sufficiently investigated in alcoholic liver diseases. An exploratory study was conducted in 136 participants, 66 abstinent patients with AUD seeking treatment for alcohol (alcohol group), and 70 healthy control subjects (control group). The alcohol group was divided according to the presence of comorbid liver diseases (i.e., fatty liver/steatosis, alcoholic steatohepatitis, or cirrhosis). All participants were clinically evaluated, and plasma concentrations of total LPA and ATX were measured using enzyme-linked immunosorbent assays. Data were primarily analyzed using analysis of covariance (ANCOVA) while controlling for age, body mass index, and sex. Logistic regression models were created to assess the association of the ATX-LPA axis and AUD or liver disease. LPA and ATX were log10-transformed to fit the assumptions of parametric testing.The main results were as follows: total LPA and ATX concentrations were dysregulated in the alcohol group, and patients with AUD had significantly lower LPA (F(1,131) = 10.677, p = 0.001) and higher ATX (F(1,131) = 8.327, p = 0.005) concentrations than control subjects; patients with AUD and liver disease had significantly higher ATX concentrations (post hoc test, p 10.3390/biomedicines9091207 2227-9059 Biomedicines http://hdl.handle.net/10668/18553 34572393 http://hdl.handle.net/20.500.12105/18463 alcohol use disorder autotaxin comorbidity liver disease lysophosphatidic acid Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease.