2026-05-17T05:56:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184502024-09-21T23:08:37Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16962

00925njm 22002777a 4500 dc Torrillas de la Cal, Alejandro author Paniagua-Torija, Beatriz author Arevalo-Martin, Angel author Faulkes, Christopher Guy author Jiménez, Antonio Jesús author Ferrer, Isidre author Molina-Holgado, Eduardo author Garcia-Ovejero, Daniel author 2021-08-28 In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in humans, the central canal is lost in the majority of individuals from early childhood. It is replaced by a structure that does not proliferate after damage and is formed by large accumulations of ependymal cells, strong astrogliosis and perivascular pseudo-rosettes. We inform here of two additional mammals that lose the central canal during their lifetime: the Naked Mole-Rat (NMR, Heterocephalus glaber) and the mutant hyh (hydrocephalus with hop gait) mice. The morphological study of their spinal cords shows that the tissue substituting the central canal is not similar to that found in humans. In both NMR and hyh mice, the central canal is replaced by tissue reminiscent of normal lamina X and may include small groups of ependymal cells in the midline, partially resembling specific domains of the former canal. However, no features of the adult human ependymal remnant are found, suggesting that this structure is a specific human trait. In order to shed some more light on the mechanism of human central canal closure, we provide new data suggesting that canal patency is lost by delamination of the ependymal epithelium, in a process that includes apical polarity loss and the expression of signaling mediators involved in epithelial to mesenchymal transitions. 10.3390/cells10092235 2073-4409 Cells http://hdl.handle.net/10668/18547 34571884 http://hdl.handle.net/20.500.12105/18450 ependymal cell epithelial to mesenchymal transition neural stem cells repair spinal cord injury The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.