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oai:repisalud.isciii.es:20.500.12105/184322024-09-21T19:58:29Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16969col_20.500.12105_16980col_20.500.12105_16983

00925njm 22002777a 4500 dc Wang, Xuejie author Villa, Carmen author Dobarganes, Yadira author Olveira, Casilda author Girón, Rosa author García-Clemente, Marta author Máiz, Luis author Sibila, Oriol author Golpe, Rafael author Menéndez, Rosario author Rodríguez-López, Juan author Prados, Concepción author Martinez-García, Miguel Angel author Rodriguez, Juan Luis author de la Rosa, David author Duran, Xavier author Garcia-Ojalvo, Jordi author Barreiro, Esther author 2021-08-10 Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann-Whitney U test and eosinophil count threshold: 100 cells/µL) showed the most balanced cluster sizes: above-threshold and below-threshold groups. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status, while showing lower systemic inflammation levels. The proportion of patients with mild disease was higher in the above-threshold group, while the below-threshold patients were more severe. Two distinct clinical phenotypes of stable patients with non-cystic fibrosis (CF) bronchiectasis of a wide range of disease severity were established on the basis of blood eosinophil counts using a biostatistical approach. Patients classified within the above-threshold cluster were those exhibiting a mild disease, significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammatory levels. These results will contribute to better characterizing bronchiectasis patients into phenotypic profiles with their clinical implications. 10.3390/ijerph18168431 1660-4601 International journal of environmental research and public health http://hdl.handle.net/10668/18446 34444179 http://hdl.handle.net/20.500.12105/18432 biostatistical analyses clinical outcomes disease severity scores eosinophil counts multivariate analyses non-cystic fibrosis bronchiectasis phenotypic clusters Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity.