2026-04-29T12:23:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184272024-11-28T14:51:02Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Marí-Beffa, Manuel
author
Mesa-Román, Ana B.
author
Duran, Ivan
authoraffiliation
[Marí-Beffa,M; Mesa-Román,AB; Duran,I] Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, IBIMA, Málaga, Spain. [Marí-Beffa,M; Duran,I] Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Málaga, Spain.
2024-02-19T15:30:28Z
2024-02-19T15:30:28Z
2021-08-05
10.3389/fgene.2021.675331
1664-8021
Frontiers in Genetics
http://hdl.handle.net/10668/4068
34490030
http://hdl.handle.net/20.500.12105/18427
In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a reference list of recognized diseases in humans and their causal genes published to help clinician diagnosis and scientific research advances. Complementary to mammalian models, zebrafish has emerged as an interesting species to evaluate chemical treatments against these human skeletal disorders. Due to its versatility and the low cost of experiments, more than 80 models are currently available. In this article, we review the state-of-art of this "aquarium to bedside" approach describing the models according to the list provided by the Nosology Committee. With this, we intend to stimulate research in the appropriate direction to efficiently meet the actual needs of clinicians under the scope of the Nosology Committee.
eng
Skeletal dysplasia
Osteogenesis imperfecta
Osteoporosis
Skeletal ciliopathies
Dwarfisms
Dysostosis
Osteopetrosis
Zebrafish models
Acrocefalosindactilia
Dentinogénesis imperfecta
Ciliopatías
Disostosis
Pez cebra
Modelos animales
Zebrafish Models for Human Skeletal Disorders
review article