2026-04-29T04:09:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184252024-09-21T20:24:31Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Becerra, José author Duran, Ivan author 2021-08-03 As our life expectancy increases, specific medical conditions appear, and new challenges are met in terms of global health. Frailty has become a medical and scientific concept to define pathologies where inflammation, depressed immune system, cellular senescence, and molecular aging converge. But more importantly, frailty is the ultimate cause of death that limits our life span and deteriorates health in an increasing proportion of the world population. The difficulty of tackling this problem is the combination of factors that influence frailty appearance, such as stem cells exhaustion, inflammation, loss of regeneration capability, and impaired immunomodulation. To date, multiple research fields have found mechanisms participating in this health condition, but to make progress, science will need to investigate frailty with an interdisciplinary approach. This article summarizes the current efforts to understand frailty from their processes mediated by inflammation, aging, and stem cells to provide a new perspective that unifies the efforts in producing advanced therapies against medical conditions in the context of frailty. We believe this approach against frailty is particularly relevant to COVID-19, since people in a state of frailty die more frequently due to the hyperinflammatory process associated with this infection. 2157-6564 http://hdl.handle.net/10668/3457 http://hdl.handle.net/20.500.12105/18425 34164948 10.1002/sctm.21-0074 2157-6580 Stem Cells Translational Medicine Aging COVID-19 Frailty Immunomodulation Inflammation Mesenchymal stem cell MSC Regeneration Stem cell exhaustion Envejecimiento Fragilidad Inmunomodulación Inflamación Células madre mesenquimatosas Regeneración Inflammation, a common mechanism in frailty and COVID-19, and stem cells as a therapeutic approach