2026-06-14T05:06:45Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/184242024-11-28T15:10:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Requena-Ocaña, Nerea author Araos, Pedro author Flores, María author García-Marchena, Nuria author Silva-Peña, Daniel author Aranda, Jesús author Rivera, Patricia author Ruiz, Juan Jesús author Serrano, Antonia author Pavón, Francisco Javier author Suárez, Juan author Rodríguez de Fonseca, Fernando authoraffiliation [Requena-Ocaña,N; Araos,P; Flores,M; García-Marchena,N; Silva-Peña,D; Aranda,J; Rivera,P; Serrano,A; Pavón,FJ; Suárez,J; Rodríguez de Fonseca,F] Mental Health Clinical Management Unit, Institute of Biomedical Research of Malaga-IBIMA, Regional University. [Requena-Ocaña,N] School of Psychology, Complutense University of Madrid, Madrid, Spain. [Araos,P] Department of Psychobiology and Methodology of Behavioral Sciences, School of Psychology, University of Málaga, Málaga, Spain. [Aranda,J] School of Medicine, University of Málaga, Málaga, Spain. [Ruiz,JJ] Provincial Drug Addiction Center of Málaga, Provincial Council of Málaga, Málaga, Spain. [Pavón,FJ] Cardiac Clinical Management Unit, IBIMA, University Hospital Virgen de la Victoria, Málaga, Spain. [Suárez,J] Department of Human Anatomy, Legal Medicine and History of Science, IBIMA, Facultad de Medicina, University of Málaga, Málaga, Spain. [Requena-Ocaña,N] Laboratorio de Investigación, IBIMA, Hospital Universitario Regional de Málaga, Málaga, Spain. 2024-02-19T15:30:26Z 2024-02-19T15:30:26Z 2021-08-02 10.1038/s41598-021-95131-2 2045-2322 Scientific Reports http://hdl.handle.net/10668/3695 34341419 http://hdl.handle.net/20.500.12105/18424 Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function. eng Neuroscience Psychology Biomarkers Neurociencias Psicología Biomarcadores Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder research article