2026-08-05T11:42:13Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184242024-11-28T15:10:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Requena-Ocaña, Nerea author Araos, Pedro author Flores, María author García-Marchena, Nuria author Silva-Peña, Daniel author Aranda, Jesús author Rivera, Patricia author Ruiz, Juan Jesús author Serrano, Antonia author Pavón, Francisco Javier author Suárez, Juan author Rodríguez de Fonseca, Fernando author 2021-08-02 Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function. 10.1038/s41598-021-95131-2 2045-2322 Scientific Reports http://hdl.handle.net/10668/3695 34341419 http://hdl.handle.net/20.500.12105/18424 Neuroscience Psychology Biomarkers Neurociencias Psicología Biomarcadores Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder