2026-07-21T14:14:06Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/184182024-02-19T15:29:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16969col_20.500.12105_16980col_20.500.12105_16983
Repisalud author Wang, Xuejie author Villa, Carmen author Dobarganes, Yadira author Olveira, Casilda author Girón, Rosa author García-Clemente, Marta author Maíz, Luis author Sibila, Oriol author Golpe, Rafael author Menéndez, Rosario author Rodríguez-López, Juan author Prados, Concepción author Martinez-García, Miguel Angel author Rodriguez, Juan Luis author de la Rosa, David author Duran, Xavier author Barreiro, Esther 2024-02-19T15:29:52Z 2024-02-19T15:29:52Z 2021-07-28 10.3390/biomedicines9080905 2227-9059 Biomedicines http://hdl.handle.net/10668/18429 34440109 http://hdl.handle.net/20.500.12105/18418 We hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung function, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored. eng biomarkers bronchiectasis disease severity gender-related differences nutritional status systemic inflammation Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study. research article