2026-04-29T04:09:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184162024-11-28T15:49:51Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Tovar, Rubén
author
Gavito, Ana Luisa
author
Vargas, Antonio
author
Soverchia, Laura
author
Hernandez-Folgado, Laura
author
Jagerovic, Nadine
author
Baixeras, Elena
author
Ciccocioppo, Roberto
author
Rodríguez de Fonseca, Fernando
author
Decara, Juan
authoraffiliation
[Tovar,R; Gavito,AL; Vargas,A; Rodríguez de Fonseca,F; Decara,J] Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, UGC Salud Mental, Avda. Carlos Haya, Pabellón de Gobierno, Málaga, Spain. [Tovar,R] Facultad de Medicina, Universidad de Málaga, Málaga, Spain. [Soverchia,L; Ciccocioppo,R; Decara,J] Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy. [Hernandez-Folgado,L; Jagerovic,N] Instituto de Química Médica, CSIC, Madrid, Spain. [Baixeras,E] Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
2024-02-19T15:29:50Z
2024-02-19T15:29:50Z
2021-07-28
http://hdl.handle.net/10668/4518
http://hdl.handle.net/20.500.12105/18416
34444748
10.3390/nu13082589
2072-6643
Nutrients
Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmitoleic acid have been proposed to improve metabolic disbalance in obesity, although the mechanisms involved are not well understood. Both palmitoleic acid (POA) and oleic acid (OA) can be transformed in N-acylethanolamines (NAEs), mediating the effects of dietary POA and OA. To test this hypothesis, here, we study the effects on food intake and body weight gain of palmitoleylethanolamide (POEA) and the OA-derived NAE analogue, oleoylethanolamide (OEA), in Sprague-Dawley rats with a hypercaloric cafeteria diet (HFD). Plasma biochemical metabolites, inflammatory mediators, and lipogenesis-associated liver protein expression were also measured. The results indicate that POEA is able to improve health status in diet-induced obesity, decreasing weight, liver steatosis, inflammation, and dyslipemia. The action of POEA was found to be almost identical to that of OEA, which is an activator of the nuclear peroxisome proliferator receptor alpha (PPARα), and it is structurally related to POEA. These results suggest that the dietary administration of either POA or POEA might be considered as nutritional intervention as complementary treatment for complicated obesity in humans.
eng
N-acylethanolamine
Palmitoleylethanolamide
Monounsaturated fatty acids
Palmitoleic acid
Oleylethanolamide
Oleic acid
Peroxisome proliferator receptor alpha
Cannabinoid receptors type 1
Hypercaloric cafeteria diet
Obesity
Inflammation
Body weight
Cytokines
Insulin resistance
Ácidos grasos monoinsaturados
Ácido oléico
PPAR alfa
Receptores de cannabinoides
Ingestión de energía
Obesidad
Inflamación
Peso corporal
Citocinas
Resistencia a la insulina
Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
research article