2026-04-29T04:09:09Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184162024-11-28T15:49:51Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Tovar, Rubén author Gavito, Ana Luisa author Vargas, Antonio author Soverchia, Laura author Hernandez-Folgado, Laura author Jagerovic, Nadine author Baixeras, Elena author Ciccocioppo, Roberto author Rodríguez de Fonseca, Fernando author Decara, Juan author 2021-07-28 Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmitoleic acid have been proposed to improve metabolic disbalance in obesity, although the mechanisms involved are not well understood. Both palmitoleic acid (POA) and oleic acid (OA) can be transformed in N-acylethanolamines (NAEs), mediating the effects of dietary POA and OA. To test this hypothesis, here, we study the effects on food intake and body weight gain of palmitoleylethanolamide (POEA) and the OA-derived NAE analogue, oleoylethanolamide (OEA), in Sprague-Dawley rats with a hypercaloric cafeteria diet (HFD). Plasma biochemical metabolites, inflammatory mediators, and lipogenesis-associated liver protein expression were also measured. The results indicate that POEA is able to improve health status in diet-induced obesity, decreasing weight, liver steatosis, inflammation, and dyslipemia. The action of POEA was found to be almost identical to that of OEA, which is an activator of the nuclear peroxisome proliferator receptor alpha (PPARα), and it is structurally related to POEA. These results suggest that the dietary administration of either POA or POEA might be considered as nutritional intervention as complementary treatment for complicated obesity in humans. http://hdl.handle.net/10668/4518 http://hdl.handle.net/20.500.12105/18416 34444748 10.3390/nu13082589 2072-6643 Nutrients N-acylethanolamine Palmitoleylethanolamide Monounsaturated fatty acids Palmitoleic acid Oleylethanolamide Oleic acid Peroxisome proliferator receptor alpha Cannabinoid receptors type 1 Hypercaloric cafeteria diet Obesity Inflammation Body weight Cytokines Insulin resistance Ácidos grasos monoinsaturados Ácido oléico PPAR alfa Receptores de cannabinoides Ingestión de energía Obesidad Inflamación Peso corporal Citocinas Resistencia a la insulina Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity