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oai:repisalud.isciii.es:20.500.12105/184062024-09-21T22:46:20Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Raigon Ponferrada, Aida author Guerrero Orriach, Jose Luis author Molina Ruiz, Juan Carlos author Romero Molina, Salvador author Gómez Luque, Aurelio author Cruz Mañas, Jose author 2021-07-17 Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Thus, these tumors show wide variability in genetic expression and prognostic biomarkers. Surgical treatment is essential in the management of these patients. However, the perioperative period has been found to significantly influence survival and cancer recurrence. There is growing interest in the pro-tumoral effect of different anaesthetic and analgesic agents used intraoperatively and their relationship with metastatic progression. There is cumulative evidence of the influence of anaesthetic techniques on the physiopathological mechanisms of survival and growth of the residual neoplastic cells released during surgery. Prospective randomized clinical trials are needed to obtain quality evidence on the relationship between cancer and anaesthesia. This document summarizes the evidence currently available about the effects of the anaesthetic agents and techniques used in primary cancer surgery and long-term oncologic outcomes, and the biomolecular mechanisms involved in their interaction. 10.3390/ijms22147653 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/18243 34299272 http://hdl.handle.net/20.500.12105/18406 anaesthetic drugs and techniques biomarkers breast cancer cancer recurrence miRNA opioids propofol volatile agent Breast Cancer and Anaesthesia: Genetic Influence.