2026-05-11T15:31:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184042024-02-19T15:29:36Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Rico-Barrio, Irantzu
author
Peñasco, Sara
author
Lekunberri, Leire
author
Serrano, Maitane
author
Egaña-Huguet, Jon
author
Mimenza, Amaia
author
Soria-Gomez, Edgar
author
Ramos, Almudena
author
Buceta, Ianire
author
Gerrikagoitia, Inmaculada
author
Mendizabal-Zubiaga, Juan
author
Elezgarai, Izaskun
author
Puente, Nagore
author
Grandes, Pedro
2024-02-19T15:29:36Z
2024-02-19T15:29:36Z
2021-07-16
10.3390/biomedicines9070825
2227-9059
Biomedicines
http://hdl.handle.net/10668/18305
34356889
http://hdl.handle.net/20.500.12105/18404
Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later in life. Remarkably, an enriched environment (EE) in adulthood significantly recovers memory in mice after adolescent BD, and the endocannabinoid, 2-arachydonoyl-glycerol (2-AG), rescues synaptic plasticity and memory impaired in adult rodents upon adolescent EtOH intake. However, the mechanisms by which EE improves memory are unknown. We investigated this in adolescent male C57BL/6J mice exposed to a drinking in the dark (DID) procedure four days per week for a duration of 4 weeks. After DID, the mice were nurtured under an EE for 2 weeks and were subjected to the Barnes Maze Test performed the last 5 days of withdrawal. The EE rescued memory and restored the EtOH-disrupted endocannabinoid (eCB)-dependent excitatory long-term depression at the dentate medial perforant path synapses (MPP-LTD). This recovery was dependent on both the cannabinoid CB1 receptor and group I metabotropic glutamate receptors (mGluRs) and required 2-AG. Also, the EE had a positive effect on mice exposed to water through the transient receptor potential vanilloid 1 (TRPV1) and anandamide (AEA)-dependent MPP long-term potentiation (MPP-LTP). Taken together, EE positively impacts different forms of excitatory synaptic plasticity in water- and EtOH-exposed brains.
eng
drug addiction
endocannabinoid system
enrichment therapy
memory
synaptic plasticity
Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence.
research article